Taubes' book argues for the hypothesis that "obesity is caused by the quality of the calories, rather than the quantity, and specifically by the effect of refined and easily digestible carbohydrates on the hormonal regulation of fat storage and metabolism." The theme is that hormones are what matters with respect to obesity and related aspects of health, like heart disease. Insulin is the focus of attention, but glucagon, estrogen, growth hormone and steroids in general are all mentioned in the book. Taubes feels that way too much emphasis has been placed on eating habits. He cites a case where the same person is emaciated above the waist but obese below the waist (yes, there is a picture), and describes mice that will die of starvation without using up fat reserves.
Throughout, he also describes the interpretations given to various observations and experimental results by medical researchers. It's a very interesting case, one that illustrates the importance of going back to the methods and data used in critical experiments.
I bought the book after reading Gina Kolata's review in Sunday's New York Times (Oct. 7). Then, there was then a very interesting article ("Diet and Fat: a Severe Case of Mistaken Consensus" by John Tierney) in Tuesday's science section (Oct. 9). It is interesting to compare that article, which accepts the thesis of the book and focuses on the phenomenon of consensus view that are mistaken, with Kolata's review, which is a bit more skeptical:
"In fact, Taubes convincingly shows that much of what is believed about nutrition and health is based on the flimsiest science....She then cites a study showing that a calorie is a calorie is a calorie; the effect on weight is the same whether from fat or carbohydrate.
But the problem with a book like this one, which goes on and on in great detail about experiments new and old in areas ranging from heart disease to cancer to diabetes, is that it can be hard to know what has been left out."
I'm inclined to believe that they are both right. It's quite plausible that what really matters is both total calories (because the laws of physics are, after all, inviolable) and how rapidly they lead to an increase in blood glucose (which induces insulin, which leads to the deposition of fat). Ironically, dietary fat, which does not induce insulin, is a preferred source of calories.
What does this have to do with intermittent fasting? I fast three times each week because of evidence that the benefits of caloric restriction (prolonged healthspan) result from the activation of a genetic program rather than from reduced metabolic activity per se, and that this genetic program can also be induced by intermittent fasting. Evidence from animal models for such a genetic program is quite solid. Evidence that this program exists in humans (and it not already fully induced in most people) is less solid. What is really unclear is what that program is and how it can be induced. Much of the science described in Taubes' book will certainly bear on figuring this out.